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Enriching Case Studies with Hands-On Lab: Blood Typing
Submitted by: Tanya C.
Recommended Grade Level(s):
Appropriate for: Grades 9 – 12
Teaching Topics & Concepts:
ABO blood typing, punnett squares, multiple alleles
Standards:
HS.LS3-1: Ask questions to clarify relationships about the role of DNA and chromosomes in the coding instructions
and characteristic traits passed from parents to offspring.
Time Requirements:
Two 80 minute class periods
Description:
Students will be conducting a case study in which a female patient is pregnant with twins. The students find out through a blood
typing activity the blood types of babies and the fathers. The students perform punnett squares and determine that one baby is
from one father and the other baby from a different father. This is called Heteropaternal superfecundation. Students will need basic
knowledge of punnett squares, sterile technique and blood typing. I use this as a way to do a final assessment on their abilities to
do punnett squares and lab technique on blood typing.
Safety
• SDS for simulated blood and antisera:
https://www.wardsci.com/assetsvc/asset/en_US/id/28552200/contents
• Blood does not need to be refrigerated
• The blood components are biohazard free and can be discarded in garbage can
• Students with long hair or jewelry should tie it back before they begin
• Let students know where to dispose of waste
• Wear gloves, goggles, lab apron and covered shoes
• Wash hands with soap and water and wipe down tables at the end of the lab
!
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